Study Details and FAQ’s

Your untested relatives are at extremely high risk for having inherited a BRCA mutation.                     Women with a BRCA mutation have a breast cancer risk of 55-70% and ovarian cancer risk of 16-45%. Men with a BRCA mutation are at elevated risk for aggressive prostate cancer, along with pancreatic, and breast cancer. Many individuals at high risk for a BRCA mutation are not aware of their risks, the personal and familial implications of a mutation, or options for genetic testing and risk reduction.      

The goal of CASCADE is to ensure that your at-risk family members have access to high quality genetic education at no cost so that they can make an informed decision about whether genetic testing is right for them. The study is designed to simplify, streamline, and enhance access to genetic education and optional genetic testing. All participants will have the option to pursue genetic testing through the study. If your relatives opt for testing, it will be provided with the utmost attention to privacy concerns.

Even if you are not sure of your relatives’ interest in testing, we ask that you please provide us with their contact information so that we can send them a study information packet. The information provided in this study could be important for them. Regardless of whether they opt for genetic testing, the information that you and they provide will make a crucial contribution to this research. All information gathered during this study is protected and will remain confidential.     

Please join us in this important endeavor to improve genetic education and testing opportunities for families at risk of BRCA mutations. Together, we can make a significant impact on cancer prevention and management for future generations.     

Study FAQ’s

What is the CASCADE study about?

The CASCADE study focuses on enhancing access and simplifying the genetic education and testing process for hereditary cancer families using an Internet-based program.

What do I need to do as a participant in the CASCADE study?

As a participant, you are required to complete a brief survey about your family, provide contact information for your untested relatives so that we can send them information about the CASCADE study, inform your male and female relatives about CASCADE, and complete a brief follow-up survey at the end of the study.

What is required from my relatives to participate in the study?

A: If you relatives wish to participate, they will be asked to complete a brief survey, agree to be randomly assigned to receive either a web-based individually tailored genetic education tool or standard resources about BRCA1/2 testing, and complete two brief follow-up surveys at 1 month and 6 months after enrollment     .

Is participation in the CASCADE study voluntary?

Yes, participation in the CASCADE study is entirely voluntary, and genetic testing is not required as part of the study.

What are the eligibility requirements for participation in the CASCADE study?

To be eligible, your blood relative(s) must be between 21 and 75 years old and be a sibling, child, nephew, niece, aunt, or uncle of an individual with a mutation in the BRCA1 or BRCA2 gene. They are not eligible if they have been diagnosed with metastatic cancer, have had prior genetic testing for BRCA1/2 gene mutations, have one or more children who tested positive for a BRCA1/2 gene mutation, or cannot participate in English.

What are the benefits of participating in the CASCADE study?

Participants may receive access to a genetic education website and can opt for genetic testing. Additionally, the study aims to provide valuable information to families at risk of BRCA mutations, potentially impacting cancer prevention and management for future generations.

What is the purpose of the follow-up surveys in the CASCADE study?

The follow-up surveys are designed to track the progress and outcomes of participants and their relatives throughout the study. They help us evaluate the effectiveness of the intervention and gather feedback on participants’ experiences.

Is there compensation for participating in the CASCADE study?

Yes, all participants will receive a $25 gift card as a token of appreciation for their time and participation in the study.

How long does it take to complete the initial survey for the CASCADE study?

The initial survey typically takes about 5 to 10 minutes to complete and provides essential information about your family history and potential eligible relatives.

Can participants in the CASCADE study choose not to proceed with genetic testing?

Yes, participation in genetic testing is entirely voluntary, and participants can choose not to proceed with testing if they prefer.

What languages are supported for participation in the CASCADE study?

Currently, participation in the CASCADE study is conducted in English. Participants must be able to participate and understand English to be eligible for the study.

How can I refer my relatives to participate in the CASCADE study?

You can refer your relatives by providing their contact information to the CASCADE study team, who will then send them information about the study and invite them to participate. 

Can I access the genetic education website even if I choose not to participate in genetic testing?

Yes, participants who choose not to proceed with genetic testing can still access the genetic education website and benefit from the information provided.

What should I do if I have more questions about the CASCADE study?

If you have more questions or need further clarification about the CASCADE study, you can contact the study team directly through the contact information provided on our website. We are here to assist you and provide any additional information you may need.